01About

I am a researcher in the Department of Neurosurgery at Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing. My work centers on neuro-oncology — the biology and treatment of malignant brain tumors.

My research spans the glioblastoma tumor microenvironment and tumor evolution, epigenetic mechanisms and emerging therapies for diffuse midline glioma, engineered tumor-treating-fields delivery, and molecular imaging of gliomas — combining bench experiments, single-cell and spatial multi-omics, and clinical data.

Before joining PUMCH in 2024, I trained in clinical medicine at Nanjing Medical University (2019–2024).

02News

  • Jul 2026 Our work on a ferroptosis-resistant myeloid niche in glioblastoma is out in Cancer Letters.
  • Jan 2026 My first-author review on epigenetic mechanisms and therapies in diffuse midline glioma appeared in Oncology Reports.

03Research

Glioma microenvironment & evolution

How myeloid niches, endothelial–macrophage crosstalk, and copy-number events (e.g. chr7 gain) shape glioblastoma progression, studied with single-cell and spatial multi-omics.

Emerging therapies

Epigenetically targeted strategies for H3K27M diffuse midline glioma and engineered intracranial delivery of tumor treating fields (ICE-TTF).

Imaging & clinical outcomes

[18F]FET-PET for dissecting glioma heterogeneity, brain metastasis mechanisms, and outcome studies grounded in clinical cohorts.

04Publications

  1. Ferroptosis-resistant myeloid niche shapes tumor natural evolution in glioblastoma

    Yijun Dong, Tingyu Liang, Junlin Li, Lingxiang Wu, Lingui Gu, Yiming Lian, Jiaheng Li, Yuekun Wang, Xiaoman Kang, Zhanao Xu, Hai Wang, Wenbo Wu, Kangping Huang, Wenbin Ma, Qianghu Wang, Yu Wang

    Cancer Letters, 2026 DOI PubMed

  2. Intracranial-implanted coupled electrode tumor treating fields (ICE-TTF) enable efficient and directionally tunable electric-field delivery for glioma

    Xin Yang, Xiaoman Kang, Tingyu Liang, Wenbo Wu, Hao Xing, Yiming Lian, Mingze Jiang, Wenbin Ma, Yu Wang, Chunhua Hu

    Brain Stimulation, 2026 DOI PubMed

  3. USP33 promotes lung adenocarcinoma brain metastasis by inhibiting the K48-linked ubiquitination and degradation of S100A9 and facilitating vimentin secretion

    Zihao Wang, Mengqi Chang, Yuekun Wang, Yang Qu, Wenbo Wu, Jiahui Liu, Xiaopeng Guo, Yidong Zhou, Wenbin Ma, Yu Wang

    International Journal of Biological Sciences, 2026 DOI PubMed

  4. Identification of RPA3 as a potential functional effector of chromosome 7 gain in glioblastoma

    Yulu Ge, Zhan Hu, Wenbo Wu, Wenbin Ma, Tingyu Liang, Yu Wang

    Biomedicines, 2026 DOI PubMed

  5. [18F]FET-PET in dissecting low-grade oligodendrogliomas

    Jiahui Liu, Qingqing Han, Wenbo Wu, Hai Wang, Xiaona Li, Kun Zheng, Dachun Zhao, Wenbin Ma, Xin Cheng, Xiaopeng Guo, Li Huo, Yu Wang

    Journal of Neuro-Oncology, 2026 DOI PubMed

  6. Epigenetic mechanisms and therapeutic advances in diffuse midline glioma (Review) First author

    Wenbo Wu, Wenlin Chen, Wenbin Ma, Yu Wang

    Oncology Reports, 2026 DOI PubMed

  7. ICAM1-mediated endothelial cells and macrophage interactions in modulating GBM malignant transformation

    Junlin Li, Tingyu Liang, Bo Liang, Xiaoman Kang, Wenbo Wu, Hai Wang, Huiyu Yang, Yu Wang, Wenbin Ma

    Journal of Inflammation Research, 2025 DOI PubMed

  8. Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease

    Chunyue Liu, Zixing Fu, Shanshan Wu, Xiaosong Wang, Shengrong Zhang, Chu Chu, Yuan Hong, Wenbo Wu, Shengqi Chen, Yueqing Jiang, Yang Wu, Yongbo Song, Yan Liu, Xing Guo

    EMBO Molecular Medicine, 2022 DOI PubMed

Also on PubMed · ORCID · Web of Science.

05Contact

The best way to reach me is by email: …

Department of Neurosurgery, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China